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Dr Matthew Young

Postdoctoral Associate
Principal Bioinformatician
Cancer Genomics

Matthew Young’s research focuses on comparing normal development with childhood cancer at the molecular level to better understand cancer’s origins and behavior.

Academic interests

Matthew Young’s academic interests include: 

  • Cancer genomics and transcriptomics
  • Cellular biology
  • Statistical techniques for data integration.

Degrees obtained

  • BA/BS, University of Melbourne.
  • PhD, Cantab.

Awards and prizes

  • Cambridge Australia Poynton Scholarship 2011-2014.
  • DiRAC Project grant 2013.

Biography

Matthew Young is a scientist at the Wellcome Sanger Institute specialising in the study of childhood cancers and congenital disorders at the molecular level. His current research focuses on the use of mathematical and statistical techniques to integrate different types of DNA and RNA sequencing data (particularly single cell RNA-seq). He uses these techniques to better understand the developmental origins of normal and cancerous tissues, and how the behaviours of childhood cancers relate to normal developmental processes. 

Before moving to cancer genomics, Matthew completed a PhD in Astrophysics at the Institute of Astronomy in Cambridge where he studied the conditions under which giant planets can form by the collapse of discs of gas around young stars.

Other interests

Tennis, long(ish) distance running, and science fiction.

Publications, links and resources

  • Young, M.D. et al. (2018) Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors, Science.
  • Anderson, N.D., Young, M.D., et al. (2018) Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors, Science.
  • Roerink, S.F., Sasaki N., Lee-Six, H., Young, M.D., et al. (2018) Intra-tumour diversification in colorectal cancer at the single-cell level, Nature.
  • Tarpey, P.S., Behjati, S., Young, M.D. et al. (2017) The driver landscape of sporadic chordoma, Nature Communications.
  • Young, M.D., Clarke, C.J. (2015) Binary accretion rates: dependence on temperature and mass ratio, MNRAS.
  • Young, M.D., Clarke, C.J. (2015) Dependence of fragmentation in self-gravitating discs on small-scale structure, MNRAS.

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